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Also known as: Diindolylmethane, 3,3'-Diindolylmethane
A compound derived from the digestion of indole-3-carbinol, found naturally in cruciferous vegetables such as broccoli and cabbage. Used to support oestrogen metabolism, particularly to promote conversion to less potent oestrogen metabolites. Popular for PMS, hormonal acne, and oestrogen dominance.
This page contains self-reported experiences from the Narrated community — not clinical data. Outcomes are subjective. Always consult your GP or specialist before starting, stopping, or changing any intervention.
Regulatory status does not mean an intervention is safe or unsafe. Laws vary by country — check your local regulations.
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Research context compiled from published sources
Modulates oestrogen metabolism by promoting the 2-hydroxylation pathway (producing less active 2-hydroxyoestrone) rather than the 16α-hydroxylation pathway. Also influences CYP1A2 enzyme activity and may have anti-oestrogenic effects in oestrogen-dominant tissues. Some evidence for anti-proliferative effects in cell studies.
Emerging Research
Limited human trials. Most evidence comes from animal studies or small human studies.
Limited
Only short-term data available. Long-term effects are not well understood.
Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.
Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.
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