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hormone

Combined HRT

Also known as: Femoston, Kliofem, Evorel Conti, Evorel Sequi, Elleste Duet, Angeliq

Preparations combining oestrogen and a progestogen in a single product, available in sequential (mimicking a cycle) or continuous combined (no bleed) formulations. Suitable for women with a uterus who need both oestrogen and progestogen.

This page contains self-reported experiences from the Narrated community — not clinical data. Outcomes are subjective. Always consult your doctor or specialist before starting, stopping, or changing any approach.

Regulatory status does not mean an approach is safe or unsafe. Laws vary by country — check your local regulations.

Community Experiences

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Research Context

Research context compiled from published sources

How does Combined HRT work?

Combines the actions of oestrogen (alleviating menopausal symptoms, protecting bone) and progestogen (protecting the endometrium from oestrogen-driven hyperplasia). Sequential regimens produce a monthly bleed; continuous combined regimens aim for no bleed after an initial settling period.

Research Depth

Well Studied

Extensive human research over many years, including randomized controlled trials.

Long-Term Evidence

Well Characterized

Decades of long-term safety data available from human use.

Known Interactions
Liver enzyme inducersAnticoagulantsSt John's Wort
Reported Contraindicated Populations
History of oestrogen-sensitive breast cancerUndiagnosed vaginal bleedingActive liver diseaseHistory of VTE (oral forms)
Published Dose Ranges
12 mg estradiol/mg progestogen per dayoral · once daily
BNF
25100 mcg/24hr estradiol + progestogentransdermal (patch) · twice weekly or weekly
BNF

Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.

Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.

Related Approaches

Other approaches tracked on Narrated.

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