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hormone

Estradiol Patch

Also known as: Evorel, Estraderm, Elleste Solo

Transdermal oestrogen delivered via a patch applied to the skin, changed every 3–4 days. One of the most common HRT delivery methods in the UK.

This page contains self-reported experiences from the Narrated community — not clinical data. Outcomes are subjective. Always consult your doctor or specialist before starting, stopping, or changing any approach.

Regulatory status does not mean an approach is safe or unsafe. Laws vary by country — check your local regulations.

Community Experiences

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Research Context

Research context compiled from published sources

How does Estradiol Patch work?

Delivers 17β-estradiol through the skin directly into the bloodstream, bypassing first-pass liver metabolism. This results in more stable serum oestrogen levels compared to oral routes.

Research Depth

Well Studied

Extensive human research over many years, including randomized controlled trials.

Long-Term Evidence

Well Characterized

Decades of long-term safety data available from human use.

Known Interactions
AnticoagulantsLiver enzyme inducers (rifampicin, carbamazepine, phenytoin)St John's Wort
Reported Contraindicated Populations
History of oestrogen-sensitive breast cancerUndiagnosed vaginal bleedingActive liver diseaseHistory of VTE without anticoagulationUntreated endometrial hyperplasia
Published Dose Ranges
25100 mcg/24hrtransdermal · every 3–4 days
BNF

Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.

Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.

Related Approaches

Other approaches tracked on Narrated.

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