D-Chiro-Inositol
Also known as: DCI, D-chiro-inositol supplement
A stereoisomer of inositol often used alongside myo-inositol for PCOS management. Plays a distinct role in insulin signalling, particularly in non-ovarian tissues. Typically combined with myo-inositol in a 40:1 ratio. Excessive D-chiro-inositol alone may impair oocyte quality.
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Community Experiences
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Research Context
Research context compiled from published sources
How does D-Chiro-Inositol work?
Mediates insulin action in peripheral tissues (muscle, liver, adipose) via a glycosylphosphatidylinositol second messenger system. Supports glycogen synthesis and glucose disposal. In the ovary, elevated D-chiro-inositol may impair aromatase activity, so it is used in balance with myo-inositol rather than alone at high doses.
Research Depth
Unknown
Long-Term Evidence
Limited
Only short-term data available. Long-term effects are not well understood.
Known Interactions
Reported Contraindicated Populations
Published Dose Ranges
Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.
Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.
Related Approaches
Other Supplement tracked on Narrated.
Data last updated: No data yet