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hormone

Tibolone

Also known as: Livial

A synthetic steroid with oestrogenic, progestogenic, and weak androgenic activity. Used as a continuous combined HRT option in postmenopausal women. Typically causes no withdrawal bleed and may also benefit libido.

This page contains self-reported experiences from the Narrated community — not clinical data. Outcomes are subjective. Always consult your doctor or specialist before starting, stopping, or changing any approach.

Regulatory status does not mean an approach is safe or unsafe. Laws vary by country — check your local regulations.

Community Experiences

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Research Context

Research context compiled from published sources

How does Tibolone work?

Tibolone is metabolised into three active compounds with differing receptor activity: two oestrogenic metabolites (relieve vasomotor symptoms and protect bone) and one progestogenic/androgenic metabolite (protects endometrium and may improve libido). Does not significantly stimulate breast tissue in the same way as standard HRT.

Research Depth

Well Studied

Extensive human research over many years, including randomized controlled trials.

Long-Term Evidence

Well Characterized

Decades of long-term safety data available from human use.

Known Interactions
Anticoagulants (may enhance warfarin effect)Liver enzyme inducers
Reported Contraindicated Populations
Women less than 12 months post-menopause (breakthrough bleeding risk)History of stroke or TIAHistory of breast or endometrial cancerCardiovascular diseaseUndiagnosed vaginal bleeding
Published Dose Ranges
2.52.5 mg/dayoral · once daily
BNF

Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.

Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.

Related Approaches

Other approaches tracked on Narrated.

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