Levothyroxine
Also known as: T4, Synthroid, Eltroxin, levothyroxine sodium
Synthetic thyroxine (T4) used as the standard treatment for hypothyroidism. The most commonly prescribed thyroid medication in the UK. Dose is titrated based on TSH levels. Many perimenopausal women have co-existing thyroid conditions, and thyroid symptoms can overlap significantly with menopausal symptoms.
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Community Experiences
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Research Context
Research context compiled from published sources
How does Levothyroxine work?
Replaces endogenous thyroxine (T4), which is converted peripherally to the active hormone triiodothyronine (T3) by deiodinase enzymes. T3 enters cells and binds to nuclear thyroid receptors, regulating genes involved in metabolism, energy production, thermoregulation, and cognitive function.
Research Depth
Well Studied
Extensive human research over many years, including randomized controlled trials.
Long-Term Evidence
Well Characterized
Decades of long-term safety data available from human use.
Known Interactions
Reported Contraindicated Populations
Published Dose Ranges
Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.
Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.
Related Approaches
Other approaches tracked on Narrated.
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