Liothyronine
Also known as: T3, Cytomel, liothyronine sodium
Synthetic triiodothyronine (T3), the active thyroid hormone. Sometimes added to levothyroxine (T4) in patients who do not feel well on T4 alone, though this combination therapy is not routinely recommended by NICE or the BTA. Increasingly sought privately by patients who report persistent symptoms on levothyroxine monotherapy.
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Community Experiences
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Research Context
Research context compiled from published sources
How does Liothyronine work?
T3 is the biologically active thyroid hormone that directly binds to nuclear thyroid receptors, regulating gene expression in virtually every tissue. It has a rapid onset of action and shorter half-life than T4. Some patients may have impaired T4-to-T3 conversion (e.g., DIO2 gene polymorphisms), which is a proposed rationale for combination therapy.
Research Depth
Well Studied
Extensive human research over many years, including randomized controlled trials.
Long-Term Evidence
Unknown
Known Interactions
Reported Contraindicated Populations
Published Dose Ranges
Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.
Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.
Related Approaches
Other approaches tracked on Narrated.
Data last updated: No data yet