Licorice Root
Also known as: Glycyrrhiza glabra, liquorice root, DGL
A herbal preparation from the root of Glycyrrhiza glabra. Used traditionally for adrenal support, digestive health, and inflammation. Contains glycyrrhizin, which inhibits cortisol metabolism. DGL (deglycyrrhizinated licorice) has the glycyrrhizin removed and is used specifically for digestive support without blood pressure effects.
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Community Experiences
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Research Context
Research context compiled from published sources
How does Licorice Root work?
Glycyrrhizin inhibits 11-beta-hydroxysteroid dehydrogenase type 2, the enzyme that converts active cortisol to inactive cortisone. This increases local cortisol availability, which is the proposed mechanism for adrenal support but also causes mineralocorticoid excess (sodium retention, potassium loss, elevated blood pressure) with prolonged high-dose use.
Research Depth
Unknown
Long-Term Evidence
Unknown
Known Interactions
Reported Contraindicated Populations
Published Dose Ranges
Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.
Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.
Related Approaches
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