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herbal

Saffron Extract

Also known as: Crocus sativus, Affron, saffron supplement

A standardised extract from the stigma of Crocus sativus. Used for mood support, with several RCTs showing benefit for mild to moderate depression comparable to some SSRIs. Also studied for PMS, appetite control, and libido. Relevant to perimenopausal women experiencing mood fluctuations.

This page contains self-reported experiences from the Narrated community — not clinical data. Outcomes are subjective. Always consult your doctor or specialist before starting, stopping, or changing any approach.

Regulatory status does not mean an approach is safe or unsafe. Laws vary by country — check your local regulations.

Community Experiences

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Research Context

Research context compiled from published sources

How does Saffron Extract work?

Active constituents (crocin, safranal, picrocrocin) modulate serotonin metabolism by inhibiting serotonin reuptake in synapses. Also has NMDA receptor antagonist properties and anti-inflammatory effects. May modulate the HPA axis, reducing cortisol secretion.

Research Depth

Unknown

Long-Term Evidence

Limited

Only short-term data available. Long-term effects are not well understood.

Known Interactions
SSRIs and SNRIs (additive serotonergic effect — caution)Anticoagulants (may increase bleeding risk at high doses)Antihypertensives (may potentiate blood pressure lowering)
Reported Contraindicated Populations
Pregnancy (high doses may be uterotonic)Bipolar disorder (mood activation risk — discuss with prescriber)Bleeding disorders
Published Dose Ranges
1430 mg/dayoral · once or twice daily
Clinical trials (Affron standardised)

Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.

Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.

Related Approaches

Other approaches tracked on Narrated.

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