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Also known as: Femoston progestogen, Duphaston
A synthetic progestogen used as the progestogen component in Femoston combined HRT. Structurally similar to natural progesterone and considered to have a more favourable side-effect profile than older synthetic progestogens. Does not have androgenic activity.
This page contains self-reported experiences from the Narrated community — not clinical data. Outcomes are subjective. Always consult your doctor or specialist before starting, stopping, or changing any approach.
Total Reports
15
Median Score (Wk 8)
8/10
Would Continue
73%
Avg Duration
10 wk
Most Common Goal
perimenopause
Most Reported Side Effect
Breast tenderness (40%)
Based on self-reported community data. Scores use a 1–10 scale.
Regulatory status does not mean an approach is safe or unsafe. Laws vary by country — check your local regulations.
Women who reported on Dydrogesterone mentioned using it for the following goals. This does not mean it is intended for or achieves any of these outcomes.
Aggregated patterns from 15 self-reported experiences with Dydrogesterone.
73% of women said they would continue this protocol
7.1/10 average self-reported outcome score at week 8
Most commonly reported effects: Breast tenderness, Headache, Nausea
Outcome Score Distribution (Week 8)
15 of 15 reports included a week 8 score
Would Continue Protocol
15 of 15 reports included this response
Reported Goals
Commonly Reported Effects
Percentage of reports mentioning each effect
Based on 15 self-reported experiences. This is community data, not clinical evidence. Individual outcomes vary. Discuss any intervention with your healthcare provider.
15 reports from women who tried Dydrogesterone
I gave Dydrogesterone a fair trial for my brain fog and fatigue. Some improvement in anxiety eased somewhat but my mood was still up and down persisted. Might try something different.
I gave Dydrogesterone a fair trial for my heavy periods and exhaustion. Some improvement in energy improved but my mood was still up and down persisted. It might work for others but was modest for me.
Dydrogesterone has been a genuine turning point for my sleep disruption and joint pain. I noticed I felt a bit more like myself fairly quickly. the difference was remarkable over the following weeks. I'd recommend discussing it with your GP.
Started Dydrogesterone alongside weight gain and low mood management. Week 2: I had more energy. Week 10: I felt significantly better. I'm glad I tried it.
I was sceptical about Dydrogesterone but desperate with my heavy periods and exhaustion. I noticed a subtle improvement. By week 10, the improvement was really noticeable. Best decision I made for my health.
Research context compiled from published sources
Binds selectively to progesterone receptors with high affinity, protecting the endometrium from oestrogen-induced hyperplasia. Unlike norethisterone, it lacks androgenic or oestrogenic activity, which may reduce some common progestogen side effects such as acne and mood changes.
Well Studied
Extensive human research over many years, including randomized controlled trials.
Well Characterized
Decades of long-term safety data available from human use.
Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.
Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.
Other approaches tracked on Narrated.
Data last updated: March 27, 2026