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Supplement

Melatonin

Also known as: circadin, melatonin supplement

A hormone produced by the pineal gland that regulates the sleep-wake cycle. Available on prescription in the UK (Circadin for adults over 55) and as an unlicensed supplement. Used for sleep-onset difficulty, jet lag, and circadian rhythm disruption. Melatonin production declines with age and may be further disrupted during perimenopause.

This page contains self-reported experiences from the Narrated community — not clinical data. Outcomes are subjective. Always consult your doctor or specialist before starting, stopping, or changing any approach.

Regulatory status does not mean an approach is safe or unsafe. Laws vary by country — check your local regulations.

Community Experiences

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Research Context

Research context compiled from published sources

How does Melatonin work?

Binds to MT1 and MT2 melatonin receptors in the suprachiasmatic nucleus, signalling the onset of darkness and promoting sleep readiness. Reduces core body temperature and promotes sleep onset. Also has antioxidant properties and may support immune function. Does not act as a sedative but adjusts circadian timing.

Research Depth

Well Studied

Extensive human research over many years, including randomized controlled trials.

Long-Term Evidence

Unknown

Known Interactions
Fluvoxamine (increases melatonin levels via CYP1A2 inhibition)Anticoagulants (may affect clotting — monitor)Immunosuppressants (melatonin may stimulate immune function)Sedatives and hypnotics (additive sedation)
Reported Contraindicated Populations
Autoimmune conditions (theoretical immune stimulation)Severe hepatic impairmentPregnancy
Published Dose Ranges
0.55 mg/dayoral · once daily, 1–2 hours before bedtime
BNF/clinical trials

Dose ranges from published research. Individual dosing should be determined with your healthcare provider based on your specific circumstances.

Factual research context from published sources — not a safety assessment or recommendation. Research classifications may change as new data emerges.

Related Approaches

Other Supplement tracked on Narrated.

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